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Chemotherapy—a powerful tool in the fight against cancer

Head & Neck Cancer Chemotherapy

Chemotherapy puts cancer-killing drugs into your bloodstream.

To some people, chemotherapy can sound intimidating. But if your healthcare provider has suggested chemotherapy, or simply “chemo,” you can feel assured that this treatment decision is based on medical science and what is right for your individual situation.

Chemo for head and neck cancer can be given in several ways:

  • Intravenous (IV): Chemotherapy goes directly into a vein
  • Injection: Chemotherapy is given by a shot in a muscle in an arm, thigh, or hip, or just under the skin in the fatty part of an arm, leg, or belly
  • Intra-arterial (IA): Chemotherapy goes directly into the artery that is feeding the cancer
  • Intraperitoneal (IP): Chemotherapy goes directly into the peritoneal cavity—the area that contains the intestines, stomach, liver, and ovaries
  • Topically: Chemotherapy comes in a cream that you rub onto the skin
  • Orally: Chemotherapy comes in pills, capsules, or liquids

Because these drugs move throughout the body, they can treat cancers that have spread to other organs.

When is chemotherapy used to treat head and neck cancer?

Chemo is used mainly in 3 situations:

  1. Adjuvant chemotherapy: For treatment after surgery, to reduce the risk of cancer returning, and to kill cells that may have spread
  2. Neoadjuvant chemotherapy: For treatment before surgery

Chemo is given in cycles, alternating between periods of treatment and rest. Treatment can last several months, or even longer. Some cancers will respond to therapy and some will not. Your healthcare team may adjust your treatment over time.

What are the side effects of chemo?

Anti-cancer drugs harm cells that grow quickly, including the blood cells that fight infections, the cells that line the mouth and digestive tract, and the hair follicles.

Chemo can cause some side effects, such as sores in the mouth and on the lips, loss of appetite, nausea, diarrhea, loss of hair, tiredness, skin rash, and balance problems. People being treated with chemotherapy should talk with their doctors and nurses about the side effects they are experiencing, and how best to manage them.

Managing side effects

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US.XON.10.04.030 Last Update: May 2010